江南大学粮食发酵与食品生物制造国家工程研究中心学术报告

讲座题目：The regulation of focal adhesions in durotaxis andembryonic stem cell differentiation

主讲人：张颂婧

报告时间：2022年5月15日（星期日）上午10:10

报告地点：线上腾讯会议，会议号354 323 978

主讲人简介：

张颂婧，新加坡南洋理工大学遗传与分子生物学，博士，现任新加坡南洋理工大学研究员。2009年获得江南大学生物工程专业学士学位，同年以全额奖学金前往新加坡南洋理工大学攻读博士学位，并于2014年获得遗传与分子生物学博士学位。自2009年开始致力于癌细胞以及再生医学研究。先后在新加坡科学研究局下属的基因研究所，新加坡国立大学机械生物学研究所以及新加坡南洋理工大学生命科学学院从事研究工作。

报告简介：

Integrin-based focal adhesion complexes are composed of multiple focal adhesion proteins that form mechanical links between actin cytoskeleton and extracellular matrix. Embryonic stem cells (ESC) are unspecialized cells derived from blastocyst’s inner cell mass, which are able to differentiate into any cell type and possess the capability of self-renewal. Fibroblasts are ubiquitous cells of connective tissues that are thought to play critical roles in migration, and served as feeder cells to support ESC growth. Focal adhesion complexes and the underlying mechanosignaling are not well studied in both ESC and fibroblasts. In this study, integrative biochemical and biophysical approaches are adopted to compare the compositions and functions of focal adhesions in both cell types, with particular interest in one of the key focal adhesion proteins, Zyxin. Our preliminary findings highlight the critical role of zyxin as a mechanical sensor in fibroblast durotaxis and ESC differentiation.